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ETO Sterilization Compatibility

HomeBlogsETO Sterilization Compatibility
A model of an atom representing eto sterilization.

Ethylene oxide (ETO) sterilization is a critical process in various industries, especially for sterilizing sensitive medical and laboratory equipment. Known for its ability to eliminate bacteria, viruses, and fungi without damaging the structure of heat- or moisture-sensitive materials, ETO sterilization is widely used in healthcare, pharmaceuticals, and laboratories. However, not all materials are compatible with ETO sterilization, Choosing the right materials and understanding ETO compatibility is essential for achieving safe, effective sterilization in these sensitive applications.

What is ETO sterilization?

Ethylene oxide (ETO) sterilization is a low-temperature sterilization technique that uses ethylene oxide gas to sterilize equipment and materials. Unlike high-temperature methods such as autoclaving, which rely on heat and pressure, ETO sterilization uses gas to penetrate surfaces and eliminate harmful microorganisms like bacteria, fungi, and viruses. This method is ideal for sterilizing products that cannot withstand high heat or moisture, as it maintains the integrity of sensitive materials while ensuring a sterile outcome.

Why ETO Sterilization is Essential

ETO sterilization is often the go-to method for sterilizing single-use medical devices, surgical instruments, and delicate laboratory equipment. In healthcare, for instance, certain materials in devices—such as plastic tubing or complex electronic devices—would degrade under high temperatures. ETO sterilization ensures these items remain usable while meeting stringent sterility standards. Similarly, in laboratories, where various instruments and containers must be sterilized without altering their structural integrity, ETO provides a reliable solution. It also plays an important role in the pharmaceutical industry, where product packaging often requires sterilization before being shipped to end-users or for further processing.

How ETO Sterilization Works

The ETO sterilization process is comprehensive and involves several steps to ensure effective sterilization and safety. Initially, the items to be sterilized undergo a preconditioning phase, where they are prepared in a specific environment to optimize the sterilization process. During the main exposure phase, ethylene oxide gas is introduced into a chamber, where it circulates and penetrates the surfaces of items. This phase ensures the gas reaches all surfaces and components, regardless of material thickness or complexity.

After exposure, the items enter the aeration phase. Because ETO is a toxic gas, this stage allows for the removal of any residual ethylene oxide, ensuring the products are safe for handling and use. Aeration time can vary depending on the material, with some items requiring extended periods to remove all traces of the gas.

When is ETO sterilization used?

ETO in Medical and Laboratory Settings

ETO sterilization is commonly used in healthcare settings, where sterility is critical for patient safety and infection control. Medical devices such as catheters, syringes, and complex surgical tools are often sterilized with ETO because they contain materials that would degrade under traditional high-temperature sterilization methods. This technique is also widely used in laboratories, where sensitive glassware, plastic containers, and other research tools must remain intact and sterile for accurate results.

Advantages and Limitations of ETO

One of the key advantages of ETO sterilization is its compatibility with a wide range of materials. ETO works at a low temperature, and is able to penetrate complex devices, making it an effective option for sterilizing intricate medical equipment.

However, ETO sterilization has limitations. Because ETO is a toxic substance, the sterilization process requires careful handling and specialized equipment to ensure safety. The aeration phase can also add significant time to the process, as materials need to be cleared of all residual ETO before they can be safely used. Despite these limitations, ETO remains a valuable sterilization method for applications requiring low-temperature sterilization of sensitive materials.

What materials are compatible with ETO sterilization?

ETO sterilization is compatible with a wide range of materials, including various plastics, metals, glass, and elastomers. Common plastics like polyethylene, polypropylene, and polyvinyl chloride (PVC) are frequently used in ETO-sterilized products, as they are durable and retain their properties under ETO exposure. These materials are often found in medical devices, pharmaceutical packaging, and laboratory equipment.

Material Compatibility Considerations

When determining compatibility with ETO sterilization, several factors come into play. Materials should ideally be non-porous or have low porosity, as this prevents microorganisms from residing within the material while allowing the sterilant to reach all areas. Another consideration is the material’s ability to withstand prolonged ETO exposure and aeration. Some materials may absorb residual ETO, which necessitates longer aeration times to clear the product of any toxic remnants.

Materials Sensitive to ETO Sterilization

While many materials are compatible with ETO, some may not be suitable due to potential degradation or residual ETO retention. For instance, certain adhesives and delicate electronic components may degrade or retain harmful ETO residues. It’s important for manufacturers to consult material specifications or seek guidance from ETO sterilization providers to verify the compatibility of their products before sterilization.

Learn more about ILT, the world leader in manufacturing seals and septa.

ILT ETO Compatibility

ILT’s caps and products are designed to withstand ETO sterilization without any degradation to the material or bond, ensuring reliability and durability. For added convenience, ILT also offers custom packaging solutions, including sterilization-ready packaging in specialized sterilization bags, so products arrive prepared for immediate use in sterile environments.

Read more about sterilization and ILT septa on our blog page or learn more about ILT, the world leader in manufacturing seals and septa here.